99.5% High Purity Mgf Mechano Peptide Hormones 5mg
|FOB Price:||US $1-5 / vials|
|Min. Order:||10 vials|
|Min. Order||FOB Price|
|10 vials||US $1-5/ vials|
|Payment Terms:||T/T, Paypal, Money Gram, Western Union|
- Model NO.: 99%
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Appearance: Freeze-Dried Powder
- Minimum Order Quantity: 10vials
- Storage Condition: Away From Light, Cold Storage(2-8 Degree)
- Specification: 10mg/vial
- Powder: Yes
- Certification: GMP, ISO 9001, USP, BP
- State: Solid
- Product Name: Mgf
- Usage: Fat Loss
- Packaging Details: 5mg/Vial*10vial/Kit
- Trademark: BETTLI
- Origin: China
MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
How does Mechano MGF work? - Muscle Growth!
When mechanical overload is introduced to a muscle (as by weight training), the MGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly MGF-1Ec (called the MGF splice variant of MGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of MGF-1 into MGF, production then switches towards producing a systemic release of MGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of MGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.
Recent Research and Studies Involving Mechano MGF
Insulin like MGF-1 (MGF-1) expression is implicated in myocardial pathophysiology, and two MGF-1 mRNA splice variants have been detected in rodents, MGF-1Ea and mechano-MGF (MGF). Recent research has shown that the expression pattern of MGF-1 gene transcripts in rat myocardium from 1 h up to 8 wks after myocardial infarction induced by left anterior descending coronary artery ligation. In addition, we characterized MGF-1 and MGF E peptide action and their respective signaling in H9C2 myocardial-like cells in vitro. MGF-1Ea and MGF expression were significantly increased, both at transcriptional and translational levels, during the late postinfarction period (4 and 8 wks) in infarcted rat myocardium. Measurements of serum MGF-1 levels in infarcted rats were initially decreased (24 h up to 1 wk) but remained unaltered throughout the late experimental phase (4 to 8 wks) compared with sham-operated rats. Furthermore, specific antiâ€"MGF-1R neutralizing antibody failed to block the synthetic MGF E peptide action, whereas it completely blocked MGF-1 action on the proliferation of H9C2 cells. Moreover, this synthetic MGF E peptide did not activate Akt phosphorylation, whereas it activated ERK1/2 in H9C2 rat myocardial cells. These data support the role of MGF-1 expression in the myocardial repair process and suggest that synthetic MGF E peptide actions may be mediated via an MGF-1R independent pathway in rat myocardial cells, as suggested by in vitro experiments.
Recent studies have also discovered two clones of the hybridonoma secreting monoclonal antibodies to the mechano-MGF have been developed by cell fusion technique. The monoclonal antibody of one clone recognizes the human MGF peptide that is absent in insulin-like MGF-1 (MGF-1) which comprised mostly of amino acids from 87-111. Enzyme-linked immunosorbent assay (ELISA) has further shown that there is a high affinity binding constants with the full length of the MGF and the 87-111 fragments of the clones. These can then be used for the quantitation of the MGF through sandwich type assay (Kravchenko et al. 2006).
We sell to quality Peptide
|CJC-1295 with DAC||2mg/vial*10vial/kit|
|CJC-1295 without DAC||2mg/vial*10vial/kit|
|Pentadecapeptide BPC 157||2mg/vial*10vial/kit|
Shipping /return /refund policy
We will attempt to ship most orders within 48 hours excluding weekends or holidays.
International and EU orders ship via Priority mail or DHL based on weight. Customer will be provided with tracking number. Shipment to countries with tropical clima will be in isolated pack and with cooling inlets. After receiving all products must be placed into refrigeratot to +5° C.
All Items are shipped safely and in manner that ensures safe arrival. If for any reason this is not the case then please email us and we will work with you. Each case is handled individually.
We will accepts returns if it is due to damage that is our fault or manufacturers defects. The items that we sell are peptides and as such could degrade if improperly handled. As a result we are unable to resell products once they have left our warehouse. The return must be within 15 days of the time of the purchase.
Peptides on the other hand, due to their fragile nature and us being to monitor how they were handled when they were out of care, could possibly degrade. We prefer not to accept returns of peptides due to this fact.
If you are missing an item or the item you receive is damaged, then please contact us and we will sent out a replacement free of shiping cost to you.