Melanotan II CAS 121062-08-6 Human Growth Peptides Powder for Darking Skin
|FOB Price:||US $1-6 / grams|
|Min. Order:||1 grams|
|Min. Order||FOB Price|
|1 grams||US $1-6/ grams|
|Port:||Hong Kong, Hong Kong|
|Payment Terms:||T/T, Western Union, Paypal, Money Gram, Bitcoin|
- Model NO.: 105
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- M.F.: C50h69n15o9
- Appearance: White Crystalline Powder
- Transport Package: as Requirments
- Origin: China
- Powder: Yes
- Certification: GMP, ISO 9001, USP, BP
- State: Solid
- CAS No: 121062-08-6
- M.W.: 1024.2
- Trademark: BETTLI
- Specification: 88
- HS Code: 3001200020
Purity (by HPLC): 99.00%
Appearance: White Powder
CAS Number: 121062-08-6
Molecular Formula: C50H69N15O9
Molecular weight: 1024.2
Storage Condition; away from light, cold storage (2-8 degree)
Usage: prevention sunlight-induce skin cancer; Sexual Dysfunction & Fat Decomposition
Melanotan II Acetate Molecular Formula:C50H69N15O9 Molecular Weight:1024.2 SPECIFICATIONS: 1.Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0° 2 .Water Content(Karl Fischer) : ≤5.0%
Melanotan II is a highly potent synthetic peptide analogue of α-MSH that may elicit melanogenic, aphrodisiac and anorectic effects through non-selective stimulation of melanocortin receptors. Melanotan-II consists of seven amino acids and is a cyclic, shortened lactam variant of alpha-Melanocyte-stimulating hormone (α-MSH), a multifunctional peptide that regulates a broad array of physiological functions. Melanotan II has been studied extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenic properties.
Melanotan and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan II has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan II is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (a-MSH).
The effects of Melanotan 2 on the diet and food intake of the laboratory mice have also been investigated. It has been demonstrated that the central melanocortin (MC) has been activated by melanotan 2 when fed and induced in the mice. The six-day treatment of Melanotan 2 has shown that the peptide actually reduced the body weight and the adipose tissue in the viscera of the mice and suppressed the caloric intake of the organism. This has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Furthermore, the same study has also demonstrated that there was a sustained increase in the available oxygen consumption in obese animals. Melanotan 2 also helped reduced the level of serum insulin and the cholesterol levels when compared with the control treatments. Furthermore, it has been suggested that melanotan 2 actually lowers the level of acetylcholine A caboxylase expression and even prevented the reduction of carnitine and palmitoltransferase I mRNA in muscle-type tissues by pair-feeding in the muscles of the obese rats. Moreover, the Melanotan 2 peptide actually increased the fat catabolism in the muscles and even improved the cholesterol metabolism (Li et al. 2004).
α-Melanocyte-stimulating hormone (α-MSH) is a naturally occurring endogenous melanotan peptide hormone of the melanocortin family, which is considered to be the most important of the melanocyte-stimulating hormones when it comes to stimulating melanogenesis, a process which in mammals is responsible for hair and skin pigmentation. α-MSH also plays a role in feeding behavior, energy homeostasis, and sexual activity (Bremelanotide and Melanotan 2). α-MSH is a nonselective agonist of melanocortin receptors MC1, MC3, MC4 and MC5. Melanotan 1 and Melanotan 2 activate the MC1 receptor, which is responsible for effects on skin pigmentation. Melanotan 2 and PT-141 both stimulate the MC3 and MC4 receptors which are responsible for the regulation of appetite, metabolism, and sexual behavior. However, PT-141 Bremelanotide does not stimulate the MC1 receptor.
A few synthetic analogues of α-MSH have been investigated for their apparent photoprotective effects against ultraviolet (UV) radiation from the sun, namely Melanotan (afamelanotide) and Melanotan II, referred to as Melanotan 2. Bremelanotide, another analogue of α-MSH similar to Melanotan 2, is currently under development for the treatment of sexual dysfunction. All of these melanotan peptides have significantly greater potencies than α-MSH, but with distinctive selectivity peptide profiles.
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